On the 27th and 28th of September the caravan crossed Indiana. This is the journal of William Campbell, traveling to Saint Charles Missouri with Archer Alexander.
An epidemic of cholera broke out in Hindostan in 1820. Water- and insect-borne illnesses were the bane of many towns on the Midwestern frontier. Situated along rivers for the purpose of easy transportation, towns were often built on flood plains that bred insects in huge numbers.